Extensive allele‐specific translational regulation in hybrid mice

Extensive allele-specific translational regulation in hybrid mice

Translational regulation is mediated through the interaction between diffusible trans-factors and cis-elements residing within mRNA transcripts. In contrast to extensively studied transcriptional regulation, cis-regulation on translation remains underexplored. Using deep sequencing-based transcriptome and polysome profiling, we globally profiled allele-specific translational efficiency for the ...

Extensive translational regulation during seed germination revealed by polysomal profiling

This work investigates the extent of translational regulation during seed germination. The polysome occupancy of each gene is determined by genome-wide profiling of total mRNA and polysome-associated mRNA. This reveals extensive translational regulation during Arabidopsis thaliana seed germination. The polysome occupancy of thousands of individual mRNAs changes to a large extent during the germ...

Extensive translational regulation of gene expression in an allopolyploid (Glycine dolichocarpa).

All flowering plants have experienced repeated rounds of polyploidy (whole-genome duplication), which has in turn driven the evolution of novel phenotypes and ecological tolerances and been a major driver of speciation. The effects of polyploidy on gene expression have been studied extensively at the level of transcription and, to a much lesser extent, at the level of the steady state proteome,...

Translational regulation in development

Controlling gene expression by regulating translation allows a cell to respond to environmental cues more quickly than de novo transcription permits. Translation of mRNAs transcribed during early oogenesis has long been known to be repressed to permit accumulation of mRNAs for use later in development. In addition to providing such a stockpile of mRNAs, translational regulation has recently bee...

Translational regulation in the chloroplast.